WikiDrug / Antiemetics / Dimenhydrinate

Dimenhydrinate for Motion Sickness Relief

Overview

Dimenhydrinate is an oral medication available as standard tablets and chewable tablets used to prevent and treat symptoms related to motion sickness. It helps relieve nausea, vomiting, and dizziness commonly associated with travel.

What is it used for?

Dimenhydrinate is used for the prevention and treatment of nausea, vomiting, and dizziness caused by motion sickness in adults and children. It is suitable for use in:

  • Adults and children 12 years and older
  • Children aged 6 to under 12 years
  • Children aged 2 to under 6 years

Active ingredients

Dimenhydrinate

How it works

Dimenhydrinate works by blocking signals to the brain that trigger nausea and vomiting. It acts as an antiemetic by antagonizing histamine receptors involved in motion sickness symptoms.

Dosage and administration

Motion Sickness Relief Tablet (Standard Tablet)

  • Prevention: Take the first dose ½ to 1 hour before starting travel or motion activity.
  • Adults and children 12 years and over: 1 to 2 tablets every 4 to 6 hours; do not exceed 8 tablets in 24 hours.
  • Children 6 to under 12 years: ½ to 1 tablet every 6 to 8 hours; do not exceed 3 tablets in 24 hours.
  • Children 2 to under 6 years: ½ tablet every 6 to 8 hours; do not exceed 1½ tablets in 24 hours.

Dramamine Orange Tablet, Chewable

  • Prevention: Take ½ to 1 hour before travel or motion activity.
  • Adults and children 12 years and over: 1 to 2 chewable tablets every 4 to 6 hours; do not exceed 8 chewable tablets in 24 hours.
  • Children 6 to under 12 years: ½ to 1 chewable tablet every 6 to 8 hours; do not exceed 3 chewable tablets in 24 hours.
  • Children 2 to under 6 years: ½ chewable tablet every 6 to 8 hours; do not exceed 1½ chewable tablets in 24 hours.

Follow dosing instructions carefully and do not exceed the maximum daily limits unless directed by a doctor.

Contraindications

  • Use in children under 2 years of age is contraindicated unless directed by a doctor.

Warnings and precautions

  • Do not use in children under 2 years of age unless directed by a doctor.
  • Consult a doctor before use if you have a breathing problem such as emphysema or chronic bronchitis, glaucoma, or difficulty urinating due to an enlarged prostate.
  • Avoid use with sedatives or tranquilizers unless advised by a doctor.
  • Marked drowsiness may occur; use caution when driving or operating machinery.
  • Avoid alcoholic beverages as alcohol and sedatives can increase drowsiness.
  • In case of overdose, seek immediate medical help or contact a Poison Control Center.

Side effects

Common side effects include drowsiness and dizziness. Marked drowsiness may occur, especially when combined with alcohol, sedatives, or tranquilizers. Serious side effects are rare but may include difficulty urinating or breathing problems in susceptible individuals.

Drug interactions

  • Alcohol, sedatives, and tranquilizers may increase drowsiness caused by dimenhydrinate.
  • Caution is advised when taking dimenhydrinate with sedative or tranquilizer medications.

Pregnancy and breastfeeding

If pregnant or breastfeeding, ask a health professional before use.

Overdose information

In case of overdose, get medical help or contact a Poison Control Center immediately.

Storage

Store at controlled room temperature, generally 20-25°C (68-77°F), with excursions permitted between 15°-30°C (59°-86°F). Protect from moisture. Do not use if the outer package is opened or blister is torn or broken.

Available dosage forms

Medical references

  • U.S. National Library of Medicine – DailyMed
  • Official prescribing information
  • Other authoritative medical references, where applicable

References are used to support the medical information presented on this page.

Medical information disclaimer

The information on WikiDrug is provided for educational and informational purposes only. It is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making decisions about medication use.

Last updated November 5, 2026