Candesartan cilexetil and hydrochlorothiazide tablets for treating hypertension

This medicine combines candesartan cilexetil and hydrochlorothiazide in tablet form to help lower high blood pressure (hypertension) by expanding blood vessels and removing excess fluid, thereby reducing cardiovascular risk.

Indication: This medication is used to treat hypertension (high blood pressure) in adult patients. It is specifically formulated as an oral tablet combining candesartan cilexetil and hydrochlorothiazide.

Candesartan cilexetil, Hydrochlorothiazide

Candesartan is an angiotensin II receptor blocker that relaxes blood vessels by preventing angiotensin II from tightening them, while hydrochlorothiazide is a thiazide diuretic that helps eliminate excess salt and water through the kidneys. Together, they reduce blood pressure by dilating blood vessels and decreasing fluid volume in the body.

Available strengths: 16 mg/12.5 mg, 32 mg/12.5 mg, and 32 mg/25 mg tablets taken orally.

Dosage is individualized based on patient response and medical supervision.

This medicine is contraindicated in patients with hypersensitivity to candesartan, hydrochlorothiazide, sulfonamide-derived drugs, or any component of the formulation, as well as in those with anuria or severe kidney impairment.

Important warnings and precautions:

• Monitor blood pressure regularly to avoid hypotension.
• Use caution in patients with impaired kidney or liver function, electrolyte imbalances, or a history of angioedema.
• Regular monitoring of kidney function and electrolytes is recommended during treatment.

Potential side effects may include dizziness, electrolyte disturbances, increased urination, or allergic reactions. Serious adverse effects require prompt medical attention.

This combination may interact with other antihypertensive agents, potassium supplements, lithium, NSAIDs, and other diuretics, possibly altering their effects or increasing the risk of adverse reactions. Medical supervision is required when used concurrently with interacting drugs.

Use during pregnancy is generally not recommended due to potential fetal risk. Women of childbearing potential should use effective contraception. The safety of this medicine during breastfeeding is not established; consult healthcare providers.

Overdose may lead to severe hypotension, electrolyte imbalance, or kidney failure. Treatment includes supportive measures, monitoring vital signs, and correcting electrolyte disturbances.

Store tablets at controlled room temperature, protected from moisture and light, and keep out of reach of children.