WikiDrug / Allergy / Benadryl

Benadryl for Temporary Relief of Allergy and Cold Symptoms

Overview

Benadryl is an antihistamine medication containing diphenhydramine hydrochloride. It is commonly used to temporarily relieve symptoms caused by hay fever, other upper respiratory allergies, and the common cold, such as sneezing, runny nose, and itchy, watery eyes.

What is it used for?

Benadryl is indicated for temporary relief of:

  • Symptoms due to hay fever or other upper respiratory allergies, including runny nose, sneezing, itchy, watery eyes, and itching of the nose or throat.
  • Symptoms due to the common cold, such as runny nose and sneezing.

It is intended for use in adults and children 6 years and older; not for use in children under 6 years of age.

Active ingredients

Diphenhydramine HCl 25 mg

How it works

Benadryl contains diphenhydramine, an antihistamine that works by blocking histamine, a natural substance in the body that causes allergy symptoms. By preventing histamine from binding to its receptors, it helps reduce sneezing, runny nose, itching, and watery eyes.

Dosage and administration

Take every 4 to 6 hours as needed, or as directed by a doctor. Do not exceed 6 doses in 24 hours.

Adults and children 12 years and older: 1 to 2 tablets per dose.

Children 6 to under 12 years: 1 tablet per dose.

Children under 6 years: Do not use.

Contraindications

  • Do not use to induce sleepiness in children.
  • Do not use with any other product containing diphenhydramine, including topical forms.

Warnings and precautions

  • Do not use to make a child sleepy.
  • Do not use with any other product containing diphenhydramine, including topical forms.
  • Avoid use if you have breathing problems such as emphysema or chronic bronchitis, glaucoma, or trouble urinating due to an enlarged prostate without consulting a doctor.
  • Taking sedatives or tranquilizers may increase drowsiness; consult a doctor or pharmacist before use.
  • Marked drowsiness may occur; avoid alcoholic drinks while using this product.
  • Be careful when driving or operating machinery due to possible drowsiness.
  • Excitability may occur, especially in children.
  • If pregnant or breastfeeding, consult a health professional before use.
  • Keep out of reach of children. In case of overdose, seek medical help or contact a Poison Control Center immediately.

Side effects

Use of Benadryl may cause marked drowsiness. Excitability can also occur, particularly in children. Avoid alcohol and other sedatives to reduce increased drowsiness risk. Serious side effects are not detailed in the label.

Drug interactions

  • Concomitant use with sedatives or tranquilizers may enhance drowsiness.
  • Do not use with other diphenhydramine-containing products, including topical ones, to prevent overdose.

Pregnancy and breastfeeding

If pregnant or breastfeeding, ask a health professional before use.

Overdose information

In case of overdose, get medical help or contact a Poison Control Center immediately (1-800-222-1222).

Storage

Store between 20°C and 25°C (68°F to 77°F). Protect from light. Do not use if pouch is torn or damaged.

Manufacturer(s)

Medical references

  • U.S. National Library of Medicine – DailyMed
  • Official prescribing information
  • Other authoritative medical references, where applicable

References are used to support the medical information presented on this page.

Medical information disclaimer

The information on WikiDrug is provided for educational and informational purposes only. It is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making decisions about medication use.

Last updated November 4, 2026